“Over 1.25 million children who were at least 1 year old assessed for long-term outcomes after preterm exposure to antenatal corticosteroids”

The systematic review and meta-analysis “Evaluation of Long-term Outcomes Associated with Preterm Exposure to Antenatal Corticosteroids” by Kiran Ninan et al. on April 11th 2022, JAMA Pediatrics, generated media interest and was also the subject of a commentary entitled “Use of Antenatal Corticosteroids for Risk of Preterm Birth—Is Timing Everything?” by Dr. Andrea Duncan and colleagues of the CHOP Research Institute in Philadelphia, published in JAMA Pediatrics on April 11th 2022. 

Ninan et al. found that in children born late preterm and at term, the use of antenatal corticosteroids was associated with an increased adjusted risk of neurocognitive and psychological harm. Moreover, half of the children exposed to preterm antenatal corticosteroids ended up being born at term.  

Duncan et al. emphasized this in the commentary, writing that, “As obstetrical and neonatal-perinatal care continue to evolve and improve, findings such as those presented by Ninan et al. should generate new hypotheses and hope.” Moreover, Helio writer Rose Weldon emphasizes a crucial point: “Findings from a systematic review and meta-analysis of long-term outcomes associated with preterm exposure to antenatal corticosteroids suggest that the timing and dose of administration “should be carefully considered.”” Additionally, journalist Amanda D’Ambrosio frames this review as eliciting a paradigm shift on antenatal corticosteroid administration. D’Ambrosio quotes Duncan et al. on how shifting “the timing of receipt” to “the timing of delivery” is crucial. This indicates a major trajectory change for the future of studying this area.  

The study was featured in several online news sites:

Dali S, “Antenatal Corticosteroids Pose Risk of Neurodevelopmental Impairment in Preemies: Study”. Medical Dialogues Daily Dose of Health & Medical News. Published online April 11, 2022. https://medicaldialogues.in/pediatrics-neonatology/news/antenatal-corticosteroids-pose-risk-of-neurodevelopmental-impairment-in-preemies-study-91364.  

D’Ambrosio A, “Antenatal Steroids May Pose Neurologic Risk to Babies Born Full Term—Birth timing—not just dose timing—linked to safety and efficacy of antenatal steroids”. MedPage Today. Published online April 11, 2022. https://www.medpagetoday.com/pediatrics/generalpediatrics/98158.  

Weldon R, “Study findings warrant caution in administering antenatal corticosteroids”. Healio. Published online April 15, 2022. https://www.healio.com/news/primary-care/20220415/study-findings-warrant-caution-in-administering-antenatal-corticosteroids 

CONGRATULATIONS TO DR. MARINELA GRABOVAC AT RT WEAVER DAY!

We would like to congratulate Dr. Marinela Grabovac for her presentation entitled “Impact of Deferred Cord Clamping on Mortality and Severe Neurological Injury in Twins Born at < 30 Weeks Gestation.” She did a great job, with impactful slides and a smooth delivery!

Dr. Grabovac was awarded the “Best Resident Research Award” for her presentation at the Department of Obstetrics & Gynecology RT Weaver Research Day.

CONGRATULATIONS TO YUN-YI CUI FOR HER RECENT PUBLICATION!

Congratulations to Ms. Yun-Yi Cui (BHSc student) for her publication entitled “Two Thirds of Surveyed Parents Would Want to Participate in a Randomized Control Trial Comparing Two Doses of Antenatal Corticosteroids to a Single Dose and Matching Placebo” (F Bacchini, Dr. K Murphy, Dr. T Lacaze-Masmonteil, Dr. E Asztalos, Dr. P Shah, under the supervision of Dr. S McDonald) in the Journal of Obstetrics and Gynaecology Canada!

Thank you Yun-Yi for your ongoing commitment to excellence in research and dedication to the team!

This publication can be viewed online here.

CONGRATULATIONS TO KIRAN NINAN FOR HIS ORAL PRESENTATION ON LONG TERM OUTCOMES AFTER ANTENATAL STEROID EXPOSURE!

We would like to congratulate Kiran Ninan, a MSc student on our team, for his presentation entitled, “Long-term neurodevelopmental and psychological outcomes after prenatal exposure to antenatal corticosteroids: A systematic review and meta-analysis”.  The systematic review found that antenatal corticosteroid (ACS) exposure may be associated with increased risks of mental/behavioural disorders, suggesting a need for caution with ACS administration.

The presentation was recognized as the Best Obstetrics Oral amongst all junior members at the 77th Annual Clinical and Scientific Conference of the Society of Obstetricians and Gynaecologists of Canada!

The abstract can be found here.

Thank you to Dr Graeme Smith and the The MotHERS™ Podcast team!

A tremendous thank you to The MotHERS Podcast team for the featured episode titled “Delayed Cord Clamping”. Click here to listen to season 1, episode 12 of the series!

The MotHERS™ podcast, hosted by Dr. Graeme Smith, aims to provide a reliable source of education about pregnancy on the internet in an effort to improve mother’s health through education, research, and screening. For more information, please visit: https://www.themothersprogram.ca/the-motherstm-podcast.

Congratulations to Sugee Korale Liyanage and Kiran Ninan for their recent publication!

Congratulations to Sugee Korale Liyanage and Kiran Ninan for their recent publication “Guidelines on Deferred Cord Clamping and Cord Milking: A Systematic Review” in Pediatrics! This article was also the subject of a commentary in the same edition, written by Douglas Blank and Susan Niermeyer!

Thank you to our wonderful team members for their ongoing commitment to excellence in research and dedication to the team!

This publication can be viewed online here.

The commentary can be viewed online here.